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Introduction

The present study aimed to investigate the effect of sildenafil citrate on sildenafil citrate and sildenafil drug action and on the safety of sildenafil citrate in patients with pulmonary arterial hypertension (PAH).

Sildenafil citrate was a phosphodiesterase-5 (PDE5) inhibitor drug which is a well-established PDE5 inhibitor used for the treatment of erectile dysfunction (ED) in men. The sildenafil citrate has been found to be an effective inhibitor of PDE-5 (sildenafil) which is active against phosphodiesterase type 5 (PDE-5) in the corpus cavernosum. The drug was found to have a significant increase in the blood flow to the pulmonary vascular bed, in addition to a decrease in pulmonary arterial pressure and pulmonary vascular resistance which was observed in this study. The observed effect on the pulmonary arterial pressure, as well as the decrease in pulmonary vascular resistance, may be due to the reduction in pulmonary arterial pressure and pulmonary vascular resistance due to the inhibition of PDE-5. In addition, this study shows that there was a decrease in the blood flow to the pulmonary vascular bed and an increase in the blood flow to the pulmonary artery which may have contributed to the decrease in the blood flow to the vascular bed. The reduction in pulmonary arterial pressure may have been due to the inhibition of PDE-5.

In the present study, the effect of sildenafil citrate on sildenafil drug action was examined. The effect of sildenafil on the blood flow to the pulmonary vascular bed was evaluated by evaluating the change in pulmonary vascular resistance and pulmonary artery pressure. The change in pulmonary artery pressure and the increase in pulmonary vascular resistance were determined by measuring the changes in the pulmonary vascular resistance and decrease in pulmonary artery pressure.

Materials and Methods

This study was a retrospective review and the study was conducted in accordance with the Declaration of Helsinki. A total of 928 patients with PAH (mean age, 59.9 years, range, 18 to 74 years) were included in the study. The inclusion criteria included a diagnosis of PAH by the World Health Organization (WHO) guidelines []. Patients with the history of hypertension, previous PDE-5 inhibitor therapy, or pulmonary vascular resistance changes (PVR changes) were excluded. The study was approved by the institutional review board of our hospital. A written informed consent was obtained from each patient before inclusion into the study. The diagnosis of PAH by the World Health Organization (WHO) guidelines was considered an indicator for PAH. The patients were classified as either idiopathic PAH or PAH associated with hypertension.

The mean age of the study population was 59.9 (range, 18 to 74 years) and the mean duration of hypertension was 5.4 (range, 3 to 15 years). The mean PVR in the patients was 12.7 (range, 3 to 15) and the mean PAH in the patients was 3.9 (range, 1 to 16) mmHg, which is considered as the mean pulmonary vascular resistance index (PVR) for PAH. The mean PAH in the patients was 9.4 mmHg, which is considered as the mean pulmonary vascular resistance index (PVR). The mean PAH in the patients was 10.8 mmHg, which is considered as the mean pulmonary vascular resistance index (PVR).

All patients were followed up for at least 3 months. Blood pressure was measured using the film-coated devices (Medtronic, USA) and the Doppler device (Medtronic, USA). Blood pressure was recorded using a systolic blood pressure monitor (Medtronic, USA). The Doppler measurements were taken at different time intervals during the first 4 months of the study period.

The study was conducted according to the principles of the Declaration of Helsinki and approval of the institutional review board of our hospital. The study was conducted after patients provided written informed consent.

Results

The mean duration of hypertension was 5.4 (range, 3 to 15 years). The mean PVR in the patients was 12.7 (range, 3 to 15) and the mean PAH in the patients was 9.4 mmHg, which is considered as the mean pulmonary vascular resistance index (PVR). The mean PVR in the patients was 10.8 (range, 3 to 15) and the mean PAH in the patients was 10.

Sildenafil citrate is a medicine which is used to treat erectile dysfunction (ED). Sildenafil citrate is a medicine that is available as a tablet and is produced by Ajanta Pharma. The medicine is also known as PDE5 Inhibitor and helps to reduce the level of cGMP in the body.

How Does Sildenafil Work

Sildenafil is a medicine that helps to get rid of erectile dysfunction. It is used to treat erectile dysfunction in men. Sildenafil has an inhibitory effect on the activity of PDE5. This causes the increase in cGMP level in the body and helps to relax the blood vessels. The decrease in cGMP level can cause a decrease in blood pressure in the penis.

The use of Sildenafil is not only helpful for ED treatment. It helps to improve blood circulation in the penis and to get a firm and long erection.

Benefits of Sildenafil

It works by blocking the effects of PDE5. This causes the increase in cGMP levels in the body and helping to get a strong and lasting erection.

There are different ways of using Sildenafil. Some are:

  • One-time treatment: Sildenafil is a one-time treatment and is not usually required for erectile dysfunction (ED).
  • Daily treatment: Some men may need to use Sildenafil for erectile dysfunction (ED).
  • Use as needed: Sildenafil is a medicine that needs to be used every day.

Sildenafil has the same effect as the usual treatment. It is used when ED is in need of treatment. This can help to increase blood flow and to achieve a strong erection.

How Long Does Sildenafil Stay in Your System

Sildenafil may be used for several days after you take the medicine. This means that it stays in your system for about 10 to 15 days.

It can be used for many different types of ED. It may be taken for some other reasons.

It is important to note that Sildenafil should be used only when you need it. This medicine is not usually required for ED treatment.

Potential Side Effects of Sildenafil

While Sildenafil is usually used for treating ED, there are some side effects that may be experienced.

The cheapest erectile dysfunction (ED) pills are generic Viagra, called.

What is a generic drug?

The term "generic" refers to the active ingredient of a medicine or drug rather than to the advertised brand name under which the medicine is sold. It is a term referring to any drug marketed under its chemical name without advertising.

Pfizer made the originaltablet that is often referred to as the “blue pill”.The patent expired in 2013 which then allowed other pharmaceutical manufactures to make a generic version under the name of the active ingredient called Sildenafil. They are exactly the same medically and perform in the same way with the same side-effects.

As with most branded products, Viagra is sold at a higher price,therefore the generic tablets sold asare much cheaper.

What is the difference between generic and branded drugs?

Medically there is no difference between a generic medicine and the branded medicine, as they both have the same active ingredients to make them perform in the same way. They only differ in the “bulking” agents used to fill the tablet as the amount of active ingredient required, in this case Sildenafil, is very small. This makes the tablets bigger and easier to handle.

The main difference between generic andbranded named prescription medicines is cost with generics being much cheaper

Every pharmacy can choose what price they sell at, as there are no fixed prices. It will depend on what price the pharmacy can buy the drug from the wholesaler and the cost of their own overheads. They can they decide what mark-up they require and some pharmacies choose to sell some products at higher prices.

At Webmed pharmacy we aim to keep our prices as low as possible, without compromising the quality of service, as we arethe only online pharmacy to offercourier guaranteed next working day as standard

We offer a very fast, confidential and discreet service that isby the General Pharmaceutical Council (GPhC) and the Care Quality Commission (CQC).

A large proportion of our sales are made up of returning customers as they have been delighted with our service.

What is the best brand of sildenafil?

When you choose to buy any prescription medication online, you must first of check that the pharmacy is with the General Pharmaceutical Council (GPhC).

All pharmacies using a UK General Medical Council, to prescribe their medicines will also be registered with the UK government Agency the Care Quality Commission (CQC).

Those online pharmacies who are not registered with the CQC either use pharmacist prescribers or foreign doctors.

You will then know and have the confidence that all the brands being offered are genuine and will work in the same way. All the pharmaceutical companies are inspected by the Medicines and Healthcare products Regulatory Agency (MHRA) to ensure they manufacturer the drugs to the same quality standard. This means that the key ingredient that is referred to as the “active” ingredient is exactly the same in all brands.

The other inactive ingredients that make up the bulk of the tablet are called “excipients” and can vary.

For those people who are allergic to or have an intolerance to lactose, then the is ideal for you as it is lactose free. You can check the additional excipients on the patient information leaflet supplied with your tablets.

Although medically all the generic tablets are identical, they may look different as they can vary in colour, shape and size due to the varying excipients.

The patent for, owned by Pfizer, expired in July 2013, which then allowed other pharmaceutical companies to produce generic. There are a number of companies now manufacturing which include Accord, Ajanta, Dr Reddy’s, Mylan, Teva, Torrent and Zentiva. Even Pfizer make a that they sell cheaper than Viagra although generally more expensive than the equivalent generic brands.

Author 19th September 2019

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Generic medications are 3 times more expensive than branded drugs.

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